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. 1985;39(2):146-8.
doi: 10.1159/000183359.

Observations on the chemical and physiological properties of urodiolenone, an urinary compound found in hypertension

E Neufeld, B Sklarz, S Goldberg, S Gilad, H Goldfarb, L Laurian, D S Silverberg, R Chayen

Observations on the chemical and physiological properties of urodiolenone, an urinary compound found in hypertension

E Neufeld et al. Nephron. 1985.

Abstract

Urodiolenone is a substance that appears as the glucuronide in the urine of 1 in 3 hypertensive subjects. It is a potent inhibitor of Na+, K+-ATPase in kidney tissue of the guinea pig, as measured by cytochemical assay. Chemical and mass spectrometric evidence is presented, from which it is concluded that urodiolenone is a sesquiterpenoid substance, is a bicyclic enone with a vicinal diol side chain, and has molecular formula C15H24O3.

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