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. 1985 Mar 8;227(4691):1238-40.
doi: 10.1126/science.2983420.

A second nuclear protein is encoded by Epstein-Barr virus in latent infection

K Hennessy, E Kieff

A second nuclear protein is encoded by Epstein-Barr virus in latent infection

K Hennessy et al. Science. .

Abstract

A region of the Epstein-Barr virus (EBV) genome that is important in inducing cell proliferation includes a single long open reading frame. Part of this open reading frame has been fused to the lacZ gene and expressed in Escherichia coli. Antisera to the fusion protein identify a protein in the nuclei of latently infected growth-transformed lymphocytes and in Burkitt tumor cells grown in vitro. This nuclear protein is encoded by a different virus-gene than that which encodes the previously described EBV nuclear antigen, EBNA.

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