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Case Reports
. 1979 Dec;1(3):249-54.
doi: 10.1016/0165-1781(79)90006-4.

Chronic Parkinsonism secondary to intravenous injection of meperidine analogues

G C Davis, A C Williams, S P Markey, M H Ebert, E D Caine, C M Reichert, I J Kopin
Case Reports

Chronic Parkinsonism secondary to intravenous injection of meperidine analogues

G C Davis et al. Psychiatry Res. 1979 Dec.

Abstract

Abuse of 4-propyloxy-4-phenyl-N-methylpiperidine, a meperidine congener, produced parkinsonism in a 23-year-old man. Unlike other drug-induced motor disturbances, the syndrome persisted for 18 months and responded to drugs that stimulate dopamine receptors. Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.

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