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. 1985 Jan;37(1):124-32.

HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes

R P Erickson, G L Pairitz, J M Karolyi, J J Kapur, D J Odenheimer, J S Schultz, C F Sing

HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes

R P Erickson et al. Am J Hum Genet. 1985 Jan.

Abstract

One hundred fifty-nine individuals were typed for HLA-A and B antigens and levels of isoproterenol-stimulated, lymphocyte cAMP. No significant age, sex, or caffeine effects on the natural log of the lymphocyte cAMP variable (ln cAMP) were found. A comparison of mean ln cAMP levels between individuals who carried a particular antigen (homozygous or heterozygous) and individuals who did not carry the antigen identified a highly significant decrease in ln cAMP levels associated with the HLA-B18 antigen. We estimated that 18.9% of the variability in ln cAMP was attributable to the HLA-B18 antigen. In addition, 38% of the variability in ln cAMP was attributable to factors that aggregate in families that were independent of the HLA-B18 effect. A weaker association of A10 with lymphocyte cAMP might be due to linkage disequilibrium between A10 and B18.

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