Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jan;84(1):6-8.

Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease

J B Harris, S L Pollard

Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease

J B Harris et al. Br J Pharmacol. 1985 Jan.

Abstract

Motor endplate disease (med) in the mouse is an hereditary disorder of the skeletal neuromuscular system. Affected animals suffer a 'functional denervation' of skeletal muscle (Duchen & Stefani, 1971). Muscle fibres do not respond to indirect excitation, but motor nerve terminals release transmitter spontaneously. Spontaneous transmitter release can be enhanced by raising [K+]o or by exposing muscles to red-back spider venom and functional transmission following indirect stimulation may be restored by 4-aminopyridine.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):238-50 - PubMed
    1. J Physiol. 1971 Jan;212(2):535-48 - PubMed
    1. Exp Neurol. 1974 Jan;42(1):169-80 - PubMed
    1. J Physiol. 1980 Oct;307:453-64 - PubMed
    1. J Physiol. 1980 Jan;298:185-203 - PubMed

MeSH terms