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. 1985 Jan;84(1):6-8.

Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease

J B Harris, S L Pollard

Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease

J B Harris et al. Br J Pharmacol. 1985 Jan.

Abstract

Motor endplate disease (med) in the mouse is an hereditary disorder of the skeletal neuromuscular system. Affected animals suffer a 'functional denervation' of skeletal muscle (Duchen & Stefani, 1971). Muscle fibres do not respond to indirect excitation, but motor nerve terminals release transmitter spontaneously. Spontaneous transmitter release can be enhanced by raising [K+]o or by exposing muscles to red-back spider venom and functional transmission following indirect stimulation may be restored by 4-aminopyridine.

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