doi: 10.1016/0014-2999(85)90725-3.
Effect of urapidil on beta-adrenoceptors of rat atria
- PMID: 2984023
- DOI: 10.1016/0014-2999(85)90725-3
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Effect of urapidil on beta-adrenoceptors of rat atria
Eur J Pharmacol.
.
Abstract
The effects of the antihypertensive drug urapidil were studied on chronotropic responses to isoprenaline in rat isolated atria. Urapidil (1-30 microM) antagonized the responses to isoprenaline competitively, and the pA2 value was 6.05. Thus, in addition to its alpha 1-adrenoceptor blocking action for which the pA2 value is about 7, urapidil has beta-adrenoceptor blocking activity.
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