doi: 10.1016/0014-2999(85)90726-5.
L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli
- PMID: 2984024
- DOI: 10.1016/0014-2999(85)90726-5
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L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli
Eur J Pharmacol.
.
Abstract
L-Adenyl 5'-(beta, gamma-methylene)-diphosphonate (L-AMP-PCP), a potent ATP receptor agonist in the guinea-pig bladder, was tested on the guinea-pig taenia coli. L-AMP-PCP, unlike ATP, did not relax the taenia coli, and it neither enhanced nor inhibited the action of ATP. Unlike ATP, L-AMP-PCP was not degraded by ectonucleotidases on the taenia coli. The lack of pharmacological effect of L-AMP-PCP on the taenia coli supports the suggestion that the ATP receptors here differ from those in the guinea-pig bladder.
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