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. 1985 Jan 22;108(2):197-200.
doi: 10.1016/0014-2999(85)90726-5.

L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli

S M Hourani, L A Welford, N J Cusack

L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli

S M Hourani et al. Eur J Pharmacol. .

Abstract

L-Adenyl 5'-(beta, gamma-methylene)-diphosphonate (L-AMP-PCP), a potent ATP receptor agonist in the guinea-pig bladder, was tested on the guinea-pig taenia coli. L-AMP-PCP, unlike ATP, did not relax the taenia coli, and it neither enhanced nor inhibited the action of ATP. Unlike ATP, L-AMP-PCP was not degraded by ectonucleotidases on the taenia coli. The lack of pharmacological effect of L-AMP-PCP on the taenia coli supports the suggestion that the ATP receptors here differ from those in the guinea-pig bladder.

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