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Clinical Trial
. 1985 Feb;48(2):157-9.
doi: 10.1136/jnnp.48.2.157.

Intravenous methylprednisolone for multiple sclerosis in relapse

M P Barnes, D E Bateman, P G Cleland, D J Dick, T J Walls, P K Newman, M Saunders, P J Tilley
Clinical Trial

Intravenous methylprednisolone for multiple sclerosis in relapse

M P Barnes et al. J Neurol Neurosurg Psychiatry. 1985 Feb.

Abstract

A randomised comparison is made between methylprednisolone, 1 g intravenously daily for 7 days, and a standard ACTH regime for the treatment of multiple sclerosis in acute relapse. It is found that methylprednisolone produces a more rapid clinical improvement than ACTH but confers no longer term benefit when the two treatments are compared at 3 months. It is proposed that intravenous methylprednisolone does have a role to play in the management of a patient with an acute relapse of multiple sclerosis.

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