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. 2018 May 29;18(1):601.
doi: 10.1186/s12885-018-4498-z.

Changes in ovarian cancer survival during the 20 years before the era of targeted therapy

Jung-Yun Lee  1 , Sunghoon Kim  1 , Young Tae Kim  1 , Myong Cheol Lim  2 , Boram Lee  3 , Kyu-Won Jung  3 , Jae Weon Kim  4 , Sang-Yoon Park  2 , Young-Joo Won  5
Affiliations

Changes in ovarian cancer survival during the 20 years before the era of targeted therapy

Jung-Yun Lee et al. BMC Cancer. .

Abstract

Background: The survival of patients with ovarian cancer has improved because of surgery and chemotherapy. This study aimed to estimate the changes in survival rates among Korean women with ovarian cancer prior to the introduction of targeted therapy for ovarian cancer.

Methods: Data were obtained from the Korea Central Cancer Registry regarding patients who were diagnosed with epithelial ovarian cancer between 1995 and 2014. The relative survival rates were calculated for 5-year periods using the Ederer II method. Cox proportional hazard models were created to assess the associations of demographic and clinicopathological factors with ovarian cancer survival.

Results: During the study period, 22,880 women were diagnosed with epithelial ovarian cancer. The 5-year relative survival rate improved from 57.2% during 1995-1999 to 63.8% during 2010-2014 (P < 0.001). Survival outcomes improved between 1995 and 1999 and 2010-2014 for the serous and endometrioid carcinoma subtypes (P < 0.001). However, no improvements were observed for the mucinous and clear cell carcinoma subtypes (P = 0.189 and P = 0.293, respectively). Multivariate analysis revealed that younger age, early stage, recent diagnosis, primary surgical treatment, and non-serous histological subtype were favorable prognostic factors.

Conclusion: Survival outcomes have improved for serous and endometrioid epithelial ovarian cancer in the last 20 years. However, no improvement was observed for patients with mucinous and clear cell carcinoma subtypes.

Keywords: Chemotherapy; Histology; Korea; Ovarian cancer; Surgery; Survival.

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Conflict of interest statement

Ethics approval and consent to participate

Ethical approval for the research protocol was provided by the institutional review board of the National Cancer Center (NCC2017–0168) which waived the requirement for informed consent. The authorization for data processing was obtained from the National ‘Cancer Control Act’.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Relative survival rate of ovary cancer by time period
Fig. 2
Fig. 2
Trends in relative survival rate according to histology and the time period (a) serous carcinoma (b) mucinous carcinoma (c) endometrioid carcinoma (d) clear cell carcinoma
See this image and copyright information in PMC

References

    1. Jung KW, Won YJ, Oh CM, Kong HJ, Lee DH, Lee KH. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2014. Cancer Res Treat. 2017;49(2):292–305. doi: 10.4143/crt.2017.118. - DOI - PMC - PubMed
    1. Kim SI, Lim MC, Lim J, Won YJ, Seo SS, Kang S, Park SY. Incidence of epithelial ovarian cancer according to histologic subtypes in Korea, 1999 to 2012. J Gynecol Oncol. 2016;27(1):e5. doi: 10.3802/jgo.2016.27.e5. - DOI - PMC - PubMed
    1. Lee JY, Kim EY, Jung KW, Shin A, Chan KK, Aoki D, Kim JW, Low JJ, Won YJ. Trends in gynecologic cancer mortality in east Asian regions. J Gynecol Oncol. 2014;25(3):174–182. doi: 10.3802/jgo.2014.25.3.174. - DOI - PMC - PubMed
    1. Chan JK, Cheung MK, Husain A, Teng NN, West D, Whittemore AS, Berek JS, Osann K. Patterns and progress in ovarian cancer over 14 years. Obstet Gynecol. 2006;108(3 Pt 1):521–528. doi: 10.1097/01.AOG.0000231680.58221.a7. - DOI - PubMed
    1. Wright JD, Chen L, Tergas AI, Patankar S, Burke WM, Hou JY, Neugut AI, Ananth CV, Hershman DL. Trends in relative survival for ovarian cancer from 1975 to 2011. Obstet Gynecol. 2015;125(6):1345–1352. doi: 10.1097/AOG.0000000000000854. - DOI - PMC - PubMed

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