Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May 29;18(1):127.
doi: 10.1186/s12886-018-0791-5.

Correlation of subfoveal choroidal thickness with axial length, refractive error, and age in adult highly myopic eyes

Bingqian Liu  1 , Yan Wang  2 , Tao Li  1 , Ying Lin  1 , Wei Ma  1 , Xiaohong Chen  1 , Cancan Lyu  1 , Yonghao Li  1 , Lin Lu  3
Affiliations

Correlation of subfoveal choroidal thickness with axial length, refractive error, and age in adult highly myopic eyes

Bingqian Liu et al. BMC Ophthalmol. .

Abstract

Background: Subfoveal choroidal thickness (SFCT) in highly myopic eyes was found to be correlated with increasing age, refractive error (spherical equivalent), and axial length. Which factor is the most significant predictor of SFCT remains controversial.

Methods: A hospital-based cohort of highly myopic eyes (with spherical equivalent equal to or over 6.00 diopter) were retrospectively screened. Data from only right eye in those bilateral high myopia, and unilateral high myopia in any eye, were used for analysis. Correlations among the four biometric factors were analyzed. Linear correlation was performed to analyze the predictors of SFCT.

Results: A cohort of 312 eyes from 312 adults (98 men) was enrolled. Statistical analysis showed that axial length (R = - 0.592), spherical equivalent (R = - 0.471), and age (R = - 0.296) were significantly correlated with SFCT (P < 0.001). No significant correlation was found between age and axial length, or age and spherical equivalent. Partial correlation with controlled age confirmed that axial length (R = - 0.628) was a more significant predictor of SFCT than spherical equivalent (R = - 0.507).

Conclusions: SFCT was inversely correlated with increasing age, spherical equivalent and axial length, with axial length as the most significant predictor of SFCT, in adult highly myopic eyes.

Keywords: Age; Axial length; Correlation analysis; High myopia; Refractive error; Subfoveal choroidal thickness.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The study was conducted in compliance with the principles of the Declaration of Helsinki and approved by the Ethics Committee of Zhongshan Ophthalmic Center. An informed consent was obtained from all of the included subjects.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Distribution of SFCT data associated with predictors. Left: SFCT data associated with axial length; Middle: SFCT data associated with refractive error; Right: SFCT data associated with age; о: Outlier values which were between 1.5 and 3 box lengths from either end of the box. *: Extreme values which are more than 3 box lengths from either end of the box
See this image and copyright information in PMC

References

    1. Dolgin E. The myopia boom. Nature. 2015;519(7543):276–278. doi: 10.1038/519276a. - DOI - PubMed
    1. Lyu Y, Zhang H, Gong Y, Wang D, Chen T, Guo X, Yang S, Liu D, Kang M. Prevalence of and factors associated with myopia in primary school students in the Chaoyang District of Beijing, China. Jpn J Ophthalmol. 2015;59(6):421–429. doi: 10.1007/s10384-015-0409-x. - DOI - PubMed
    1. Wu LJ, You QS, Duan JL, Luo YX, Liu LJ, Li X, Gao Q, Zhu HP, He Y, Xu L, et al. Prevalence and associated factors of myopia in high-school students in Beijing. PLoS One. 2015;10(3):e0120764. doi: 10.1371/journal.pone.0120764. - DOI - PMC - PubMed
    1. Williams KM, Bertelsen G, Cumberland P, Wolfram C, Verhoeven VJ, Anastasopoulos E, Buitendijk GH, Cougnard-Gregoire A, Creuzot-Garcher C, Erke MG, et al. Increasing prevalence of myopia in Europe and the impact of education. Ophthalmology. 2015;122(7):1489–1497. doi: 10.1016/j.ophtha.2015.03.018. - DOI - PMC - PubMed
    1. Saxena R, Vashist P, Tandon R, Pandey RM, Bhardawaj A, Menon V, Mani K. Prevalence of myopia and its risk factors in urban school children in Delhi: the North India myopia study (NIM study) PLoS One. 2015;10(2):e0117349. doi: 10.1371/journal.pone.0117349. - DOI - PMC - PubMed