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Review
. 2018 Jul 2;38(4):BSR20180448.
doi: 10.1042/BSR20180448. Print 2018 Aug 31.

Bone remodeling induced by mechanical forces is regulated by miRNAs

Yue Wang  1 , Lingfei Jia  2   3 , Yunfei Zheng  4 , Weiran Li  4
Affiliations
Review

Bone remodeling induced by mechanical forces is regulated by miRNAs

Yue Wang et al. Biosci Rep. .

Abstract

The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch (MCS), fluid shear stress (FSS), compression, and microgravity play different roles in the cell differentiation and proliferation involved in bone remodeling. However, the underlying mechanisms are unclear, particularly the molecular pathways regulated by non-coding RNAs (ncRNAs) that play essential roles in bone remodeling. Amongst the various ncRNAs, miRNAs act as post-transcriptional regulators that inhibit the expression of their target genes. miRNAs are considered key regulators of many biologic processes including bone remodeling. Here, we review the role of miRNAs in mechanical force-induced bone metabolism.

Keywords: Bone remodeling; compression; fluid shear stress; mechanical cyclical stretch; microRNA; microgravity.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Different mechanical forces play different roles in bone remodeling
Figure 2
Figure 2. miRNAs mediate the process of bone remodeling as a post-transcriptional inhibitor
See this image and copyright information in PMC

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