Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul;7(7):R238-R251.
doi: 10.1530/EC-18-0129. Epub 2018 May 29.

Cardiometabolic risk in polycystic ovary syndrome

Katica Bajuk Studen  1 , Marija Pfeifer  2
Affiliations
Review

Cardiometabolic risk in polycystic ovary syndrome

Katica Bajuk Studen et al. Endocr Connect. 2018 Jul.

Abstract

Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age. Besides hyperandrogenism, oligomenorrhea and fertility issues, it is associated with a high prevalence of metabolic disorders and cardiovascular risk factors. Several genetic polymorphisms have been identified for possible associations with cardiometabolic derangements in PCOS. Different PCOS phenotypes differ significantly in their cardiometabolic risk, which worsens with severity of androgen excess. Due to methodological difficulties, longer time-scale data about cardiovascular morbidity and mortality in PCOS and about possible beneficial effects of different treatment interventions is missing leaving many issues regarding cardiovascular risk unresolved.

Keywords: PCOS; cardiometabolic risk; cardiovascular risk; hyperandrogenism; obesity.

PubMed Disclaimer

References

    1. Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. Endocrine Reviews 2015. 36 487–525. (10.1210/er.2015-1018) - DOI - PMC - PubMed
    1. McCartney CR, Marshall JC. Polycystic ovary syndrome. New England Journal of Medicine 2016. 375 54–64. (10.1056/NEJMcp1514916) - DOI - PMC - PubMed
    1. Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED, Bartzis MI. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. Journal of Clinical Endocrinology and Metabolism 1999. 84 4006–4011. (10.1210/jcem.84.11.6148) - DOI - PubMed
    1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction 2004. 19 41–47. - PubMed
    1. Zawadski J, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In Polycystic Ovary Syndrome, pp 377–384. Eds Dunaif A, Givens HR, Haseltine FP. & Merriam G. Boston, MA, USA: Blackwell Scientific, 1992.

LinkOut - more resources