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. 2018 May;34(3):259-266.
doi: 10.6515/ACS.201805_34(3).20180207A.

The Relationship between Serum Apelin Levels and the Severity of Calcific Aortic Stenosis

Hakan Duman  1 , Ilkay Bahçeci  2 , Hikmet Hamur  2 , Selami Demirelli  3 , Aziz Ramazan Dilek  2 , Turan Erdogan  1 , Handan Duman  4 , Ömer Şatıroğlu  1 , Murtaza Emre Durakoğlugil  1
Affiliations

The Relationship between Serum Apelin Levels and the Severity of Calcific Aortic Stenosis

Hakan Duman et al. Acta Cardiol Sin. 2018 May.

Abstract

Background: Apelin, an endogenous peptide, has recently gained attention due to its positive inotropic effects in heart failure physiopathology. We investigated the relationship between serum apelin levels and the severity of calcific aortic stenosis (AS).

Methods: A total of 68 consecutive patients diagnosed with calcific AS and a control group of 32 subjects were included in the study. The subjects were divided into three group as follows: the control group, the mild-moderate AS group and the severe AS group. Blood samples were obtained from all of the subjects, which were used for biochemical comparisons of apelin 36 and high-sensitive C-reactive protein (hsCRP) levels.

Results: Plasma apelin 36 levels were significantly lower in the patients with severe AS [490 (247-1074) pg/ml] compared to both the mild-moderate AS [209 (97-453) pg/ml] and control [660 (378-1200) pg/ml] groups (p < 0.001). Correlation analysis between the left ventricular mass index and apelin concentrations revealed a significant negative correlation between the two parameters (p < 0.001, r = -0.478).

Conclusions: Our study demonstrated decreased apelin levels and increased hsCRP concentrations in patients with severe calcific AS. Our findings may help to clarify the exact pathophysiologic role of apelin in cardiovascular diseases.

Keywords: Aortic stenosis; Apelin; Apelin 36; Left ventricular hypertrophy.

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Figures

Figure 1
Figure 1
Serum apelin concentrations according to aortic stenosis and control group.
Figure 2
Figure 2
The correlation graph of apelin concentration with mean aortic gradient.
See this image and copyright information in PMC

References

    1. Tziomalos K, Athyros VG, Karagiannis A, Mikhailidis DP. Established and emerging vascular risk factors and the develop-ment of aortic stenosis: an opportunity for prevention? Expert Opin Ther Targets. 2008;12:809–820. - PubMed
    1. Chen YH, Chang HH, Chen PL, et al. Procedural characteristics and outcomes of transcatheter aortic valve implantation: a single-center experience of the first 100 inoperable or high surgical risk patients with severe aortic stenosis. Acta Cardiol Sin. 2017;33:339–349. - PMC - PubMed
    1. Sahinarslan A, Vecchio F, MacCarthy P, et al. Dynamics of concomitant functional mitral regurgitation in patients with aortic stenosis undergoing TAVI. Acta Cardiol Sin. 2016;32:477–484. - PMC - PubMed
    1. Yin WH. Transcatheter aortic valve implantation in Taiwan: still evolving! Acta Cardiol Sin. 2017;33:350–352. - PMC - PubMed
    1. Dweck MR, Boon NA, Newby DE. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol. 2012;60:1854–1863. - PubMed

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