Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Jul;8(7):e01011.
doi: 10.1002/brb3.1011. Epub 2018 May 29.

Including cannabinoids in the treatment of painful schwannomatosis

Vittorio Iorno  1 , Anna Roberto  2 , Laura Brigitta Colantonio  3 , Laura Landi  3 , Oscar Corli  2
Affiliations
Editorial

Including cannabinoids in the treatment of painful schwannomatosis

Vittorio Iorno et al. Brain Behav. 2018 Jul.

Abstract

A 47‐year‐old man, affected by Schwannomatosis, presented a very severe pain (10/10, NRS) with paroxysmal shooting episodes, allodynia, paresthesia, and dysesthesia; in parallel, the patient had lost weight (from 70 to 49 kg) and experienced fatigue and deep depression. The previous pain prescription, including opioids and antineutopathic drugs, was fully ineffective. We progressively substituted this therapy with 15 drops, 3 times/daily, of THC/CBD in a concentration ratio 5:1, equal to 15 mg of active substance each time, reaching improvement in pain intensity (6/10) and in several other aspects as mood and quality of life

PubMed Disclaimer

References

    1. Campana, W. M. , Li, X. , Shubayev, V. I. , Angert, M. , Cai, K. , & Myers, R. R. (2006). Erythropoietin reduces schwann cell TNF‐Alpha, wallerian degeneration and pain‐related behaviors after peripheral nerve injury. The European Journal of Neuroscience, 23(3), 617–626. 10.1111/j.1460-9568.2006.04606.x - DOI - PubMed
    1. Gonzalvo, A. , Fowler, A. , Cook, R. J. , Little, N. S. , Wheeler, H. , McDonald, K. L. , & Biggs, M. T. (2011). Schwannomatosis, sporadic schwannomatosis, and familial schwannomatosis: A surgical series with long‐term follow‐up. Clinical Article. Journal of Neurosurgery, 114(3), 756–762. 10.3171/2010.8.JNS091900 - DOI - PubMed
    1. Lattanzi, R. , Maftei, D. , Marconi, V. , Florenzano, F. , Franchi, S. , Borsani, E. , … Negri, L. (2015). Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model. BioMed Research International, 2015, 301292 10.1155/2015/301292 - DOI - PMC - PubMed
    1. Lewin, G. R. , Ritter, A. M. , & Mendell, L. M. (1993). Nerve growth factor‐induced hyperalgesia in the neonatal and adult rat. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 13(5), 2136–2148. - PMC - PubMed
    1. Lu‐Emerson, C. , & Plotkin, S. R. (2009). The Neurofibromatoses. Part 2: NF2 and Schwannomatosis. Reviews in Neurological Diseases, 6(3), E81–E86. - PubMed

Publication types

LinkOut - more resources