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. 1985 Jan;328(3):236-40.
doi: 10.1007/BF00515547.

In vivo demonstration of alpha-2-adrenoceptor-mediated inhibition of the excitatory non-cholinergic neurotransmission in guinea pig airways

N Grundström, R G Andersson

In vivo demonstration of alpha-2-adrenoceptor-mediated inhibition of the excitatory non-cholinergic neurotransmission in guinea pig airways

N Grundström et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 Jan.

Abstract

In anaesthetized guinea pigs, vagal nerve stimulation caused an atropine- and hexamethonium-resistant increase in the respiratory insufflation pressure. Clonidine (0.05 mg/kg i.v.) inhibited the increase in insufflation pressure caused by vagal stimulation. This effect of clonidine was antagonized by the alpha-2-antagonist yohimbine (0.5 mg/kg i.v.), but not by the alpha-1-antagonist prazosin (0.03 mg/kg i.v.). In conclusion, the increase in the respiratory insufflation pressure, caused by stimulation of noncholinergic nerves, seemed to be controlled by inhibitory alpha-2-adrenoceptors in guinea pig airways.

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References

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