Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 May;23(21):1800264.
doi: 10.2807/1560-7917.ES.2018.23.21.1800264.

Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017

Thibault Poncin  1   2 , Sebastien Fouere  3 , Aymeric Braille  1   2 , Francois Camelena  1   2   4 , Myriem Agsous  1   2 , Cecile Bebear  5 , Sylvain Kumanski  2 , Florence Lot  6 , Severine Mercier-Delarue  1 , Ndeindo Ndeikoundam Ngangro  6 , Maud Salmona  1 , Nathalie Schnepf  1   2 , Julie Timsit  3 , Magnus Unemo  7 , Beatrice Bercot  1   2   4
Affiliations
Case Reports

Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017

Thibault Poncin et al. Euro Surveill. 2018 May.

Abstract

We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.

Keywords: antimicrobial resistance; antimicrobial treatment; diagnosis; gonorrhoea; treatment failure.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared

References

    1. Wi T, Lahra MM, Ndowa F, Bala M, Dillon JR, Ramon-Pardo P, et al. Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action. PLoS Med. 2017;14(7):e1002344. 10.1371/journal.pmed.1002344 - DOI - PMC - PubMed
    1. World Health Organization (WHO). Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. Geneva: WHO; 2012. Available from: http://www.who.int/reproductivehealth/publications/rtis/9789241503501/en/
    1. European Centre for Disease Prevention and Control (ECDC). Response plan to control and manage the threat of multidrugresistant gonorrhoea in Europe. Stockholm: ECDC; 2012. Available from: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publicat....
    1. Fifer H, Natarajan U, Jones L, Alexander S, Hughes G, Golparian D, et al. Failure of dual antimicrobial therapy in treatment of gonorrhea. N Engl J Med. 2016;374(25):2504-6. 10.1056/NEJMc1512757 - DOI - PubMed
    1. Geisler WM, Uniyal A, Lee JY, Lensing SY, Johnson S, Perry RC, et al. Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection. N Engl J Med. 2015;373(26):2512-21. 10.1056/NEJMoa1502599 - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources