Controversies in dose-escalation for locally advanced non-small cell lung cancer and the role of proton beam therapy

Affiliations

¹ Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
² Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Comment

Vivek Verma et al. J Thorac Dis. 2018 Apr.

. 2018 Apr;10(Suppl 9):S1124-S1126.

doi: 10.21037/jtd.2018.03.155.

¹ Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
² Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Breaking the dose ceiling: proton therapy for locally advanced non-small cell lung cancer.
Choi JI, Simone CB 2nd. Choi JI, et al. J Thorac Dis. 2018 Jan;10(1):130-134. doi: 10.21037/jtd.2017.12.79. J Thorac Dis. 2018. PMID: 29600039 Free PMC article. No abstract available.

1. Chang JY, Verma V, Li M, et al. Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non-Small Cell Lung Cancer: Final Results of a Phase 2 Study. JAMA Oncol 2017;3:e172032. 10.1001/jamaoncol.2017.2032 - DOI - PMC - PubMed
1. Machtay M, Bae K, Movsas B, et al. Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 2012;82:425-34. 10.1016/j.ijrobp.2010.09.004 - DOI - PMC - PubMed
1. Chun SG, Hu C, Choy H, et al. Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non-Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial. J Clin Oncol 2017;35:56-62. 10.1200/JCO.2016.69.1378 - DOI - PMC - PubMed
1. McMillan MT, Ojerholm E, Verma V, et al. Radiation Treatment Time and Overall Survival in Locally Advanced Non-small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 2017;98:1142-52. 10.1016/j.ijrobp.2017.04.004 - DOI - PubMed
1. Chang JY, Jabbour SK, De Ruysscher D, et al. Consensus Statement on Proton Therapy in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 2016;95:505-16. 10.1016/j.ijrobp.2016.01.036 - DOI - PMC - PubMed