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. 2018 Apr;10(4):2397-2402.
doi: 10.21037/jtd.2018.03.186.

Clinical characteristics and prognosis of patients with lung adenosquamous carcinoma after surgical resection: results from two institutes

Lewei Zhu  1   2 , Long Jiang  3 , Jie Yang  2 , Weiquan Gu  2 , Jianxing He  1   3
Affiliations

Clinical characteristics and prognosis of patients with lung adenosquamous carcinoma after surgical resection: results from two institutes

Lewei Zhu et al. J Thorac Dis. 2018 Apr.

Abstract

Background: Adenosquamous carcinoma (ASC) is a mixed glandular and squamous cell carcinoma (SCC) with more aggressive behavior than the other histologic subtypes of lung cancer. We aim to evaluate the prognosis of patients with ASC after surgical resection.

Methods: We reviewed records of patients who underwent surgical resection for lung cancer in two institutes between January 2010 and December 2015. Survival data were collected with a median follow-up of 59 (range from 10 to 85) months. Kaplan-Meier survival curve was determined for all patients.

Results: Patients with ASC accounted for 1.6% of all NSCLC patients (33 males, 25 females). The cumulative postoperative 3- and 5-year survival rates were 56% and 48%, respectively. Overall survival (OS) was significantly lower in ASC patients than in adenocarcinoma (AC) patients operated during the same period (P<0.01). Patients with ASC containing acinar predominant AC had better survival than those with non-acinar predominant ASC (P=0.03). No difference of OS was found in patients with or without visceral pleural invasion (VPI), vascular invasion (VI) or EGFR mutation status. Multivariate analysis showed gender, pathological subtype, and TNM staging to be independent prognostic factors.

Conclusions: We demonstrated that ASC were uncommon and aggressive lung tumors. Predominant histological subtype of AC might be an independent prognostic factor for ASC. Further prospective studies are warranted to clarify the characteristics of this rare tumor.

Keywords: Lung adenosquamous carcinoma; histological subtype; prognostic factor; surgical resection.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Survival of patients with adenosquamous carcinoma (ASC) and adenocarcinoma (AC) according to time periods.
Figure 2
Figure 2
Survival of patients with adenosquamous carcinoma (ASC) according to TNM stage.
Figure 3
Figure 3
Survival of patients with adenosquamous carcinoma (ASC) according to predominant component of tumor. AC, adenocarcinoma; Sq, squamous carcinoma.
Figure 4
Figure 4
Survival of patients with adenosquamous carcinoma (ASC) according to growth pattern of adenocarcinoma in ASC.
Figure 5
Figure 5
Survival of patients with adenosquamous carcinoma (ASC) according to EGFR mutation status.
Figure 6
Figure 6
Survival of patients with adenosquamous carcinoma (ASC) according to visceral pleural invasion (VPI).
Figure 7
Figure 7
Survival of patients with adenosquamous carcinoma (ASC) according to vessel invasion (VI).
See this image and copyright information in PMC

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