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. 2018 Apr;14(2):164-170.
doi: 10.2174/1573401313666170609101408.

Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Suhad M Bahijri  1   2 , Ghada Ajabnoor  1   2 , Gehan A Hegazy  1   2   3 , Lubna Alsheikh  2 , Mai Z Moumena  2   4 , Bushra M Bashanfar  2   4 , Amal H Alzahrani  2   4
Affiliations

Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Suhad M Bahijri et al. Curr Nutr Food Sci. 2018 Apr.

Abstract

Background: Obesity is a global health problem, increasing susceptibility to Type 2 Diabetes (T2DM) and Cardiovascular Disease (CVD). Varieties of products have been proposed for treatment with varying degrees of success. Recent studies, suggested Oligonol; an optimized phenolic product mixture from Lychee Fruit Polyphenols (LFP); as such treatment in Japanese population.

Objectives: We aimed to investigate the effect of oligonol on weight, insulin resistance by (HOMA-IR), lipids profile, leptin, Adiponectin, and resistin in healthy overweight and obese Saudi females.

Subjects and methods: 60 Saudi healthy overweight and obese females were enrolled in a double blind case/control study to take either Oligonol or placebo for 12 weeks without dietary or lifestyle re-strictions. Weight, height, Waist Circumference (WC), hip circumference (HC), and blood pressure were measured, and fasting blood samples of participants were taken before, and at the end of study. Total cholesterol, HDL-cholesterol, triglycerides, glucose, insulin, leptin, adiponectin, and resistin were meas-ured. LDL- cholesterol, HOMA-IR were calculated by equation.

Results: 47 subjects completed the study, 25 in placebo group, and 22 in Oligonol group. No ill effects were noted in any participant. Oligonol reduced means of serum triglycerides (P=0.008), and resistin (P=0.045) significantly. In addition, no weight gain was noted in oligonol group, unlike placebo group which exhibited significant increase in mean weight (P= 0.036), WC (P=0.027), HC (P= 0.047), and leptin (P <0.001).

Conclusion: Oligonol could be suggested as future hypolipidemic and weight controlling agent for overweight and obese Saudi females.

Keywords: Abdominal obesity; adiponectin; insulin resistance; leptin; lipid profile; oligonol; resistin.

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Figures

Fig. (1)
Fig. (1)
Effect of supplementation on hip circumference (HC), and percentage body fat in group A (placebo), and group B (Oligonol).
See this image and copyright information in PMC

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