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. 1985 May;48(2):592-6.
doi: 10.1128/iai.48.2.592-596.1985.

Inhibition of growth of Chlamydia trachomatis by human gamma interferon

Y Shemer, I Sarov

Inhibition of growth of Chlamydia trachomatis by human gamma interferon

Y Shemer et al. Infect Immun. 1985 May.

Abstract

Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (greater than 350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.

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