Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 May 31;173(6):1318-1319.
doi: 10.1016/j.cell.2018.05.023. Epub 2018 May 31.

A "Counter-Enhancer" in Tumor Suppression

Francesco P Marchese  1 , Maite Huarte  2
Affiliations
Free article
Comment

A "Counter-Enhancer" in Tumor Suppression

Francesco P Marchese et al. Cell. .
Free article

Abstract

The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.

PubMed Disclaimer

Comment on

  • Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
    Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Cho SW, et al. Cell. 2018 May 31;173(6):1398-1412.e22. doi: 10.1016/j.cell.2018.03.068. Epub 2018 May 3. Cell. 2018. PMID: 29731168 Free PMC article.

LinkOut - more resources