doi: 10.1084/jem.161.5.1112.
Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
- PMID: 2985729
- PMCID: PMC2187616
- DOI: 10.1084/jem.161.5.1112
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Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
J Exp Med.
.
Abstract
The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
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