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. 2018 May 31;7(6):133.
doi: 10.3390/jcm7060133.

Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data

Zhenchong Xiong  1 , Lin Yang  2 , Guangzheng Deng  3 , Xinjian Huang  4 , Xing Li  5 , Xinhua Xie  6 , Jin Wang  7 , Zeyu Shuang  8 , Xi Wang  9
Affiliations

Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data

Zhenchong Xiong et al. J Clin Med. .

Abstract

Population-based estimates are lacking for the temporal trends in the contralateral breast cancer (CBC) risk for patients with breast cancer (BC). Data for BC patients diagnosed with CBC were collected from the Surveillance, Epidemiology, and End Results database. CBC incidence was calculated using the Kaplan-Meier method and the temporal trend in CBC incidence was assessed using joinpoint regression. Survival analysis was calculated using propensity scoring (PS) and multivariate Cox regression with a competing risk model. We found that 10,944 of 212,630 patients with early-stage BC were subsequently diagnosed with secondary BC in the contralateral breast. The 5-, 10-, 15-, and 20-year cumulative CBC incidences were 1.9, 4.6, 7.6, and 10.5%, respectively. Being younger (.

Keywords: SEER; contralateral breast cancer; incidence; outcome; propensity score.

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Conflict of interest statement

All authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Temporal trend in contralateral breast cancer (CBC) incidence over the 24-year follow-up period (1990–2013). (A) Cumulative incidence of CBC in early-stage breast cancer (BC). (B) Trend of CBC incidence per 1000 person-years estimated by joinpoint regression (Trend 1: years 1–11, Trend 2: years 11–21, Trend 3: years 21–24). (C) Trend in standardized incidence ratio (SIR) CBC in early-stage BC compared with the general population. * P < 0.05. NA = not available.
Figure 2
Figure 2
Overall and BC-specific survival analyses adjusted using the propensity scoring (PS) model between patients with early-stage unilateral BC and patients with early-stage CBC. All values are based on the PS model. Left - overall survival (OS): (A) entire cohort, (B) stage I, (C) stage IIA, and (D) stage IIB. Right—BC-specific survival: (E) entire cohort, (F) stage I, (G) stage IIA, and (H) stage IIB. BC = breast cancer; CBC = contralateral breast cancer.
See this image and copyright information in PMC

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