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. 2018 Oct;34(10):823-827.
doi: 10.1089/AID.2018.0018. Epub 2018 Jul 3.

Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut

Sallie Permar  1   2 , Ofer Levy  3   4   5 , Tobias R Kollman  6 , Anjali Singh  7 , Kristina De Paris  8
Affiliations

Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut

Sallie Permar et al. AIDS Res Hum Retroviruses. 2018 Oct.

Abstract

Limited success of current HIV-1 vaccines warrants new approaches. We discuss feasibility and potential benefits of early life HIV-1 immunization followed by vaccine boosts during childhood that may enable maturation of vaccine-induced broad anti-HIV-1 immunity over several years. By initiating this immunization approach in the very young, well before sexual debut, such a strategy may dramatically reduce the risk of HIV-1 infection.

Keywords: HIV prevention; immune development; vaccine.

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Conflict of interest statement

No competing financial interests exist.

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