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Review
. 2018 Jun;4(6):401-404.
doi: 10.1016/j.trecan.2018.03.010. Epub 2018 Apr 20.

B7-H3 in Cancer - Beyond Immune Regulation

Karine Flem-Karlsen  1 , Øystein Fodstad  1 , Ming Tan  2 , Caroline E Nunes-Xavier  3
Affiliations
Review

B7-H3 in Cancer - Beyond Immune Regulation

Karine Flem-Karlsen et al. Trends Cancer. 2018 Jun.

Abstract

B7-H3, a member of the B7 family of immunoregulatory proteins, is overexpressed in cancer and promotes tumor growth, metastasis, and drug resistance. We discuss here the involvement of B7-H3 in cancer that goes beyond its immune regulatory function, and discuss the potential of B7-H3 as a biomarker and therapeutic target.

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