Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 May;82(9):2623-6.
doi: 10.1073/pnas.82.9.2623.

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis

S P Watson, E G Lapetina

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis

S P Watson et al. Proc Natl Acad Sci U S A. 1985 May.

Abstract

The present study has demonstrated that pretreatment of human platelets with either phorbol ester or 1,2-diacylglycerol inhibits agonist-induced formation of inositol phosphates; this inhibition can be correlated with a decrease in the release of ATP and 5-hydroxytryptamine by thrombin. The mechanism of this action is not known, but a role for protein kinase C is suggested, as both phorbol ester and 1,2-diacylglycerol have in common the ability to activate this enzyme. These results have important implications as a possible negative feedback control over agonist-induced hydrolysis of inositol phospholipids.

PubMed Disclaimer

References

    1. J Biol Chem. 1984 Nov 10;259(21):13199-203 - PubMed
    1. Biochem Biophys Res Commun. 1984 Oct 30;124(2):507-13 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7431-5 - PubMed
    1. Blood. 1977 Nov;50(5):915-26 - PubMed
    1. J Biol Chem. 1982 Nov 10;257(21):12705-8 - PubMed

LinkOut - more resources