Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 May;82(9):2627-31.
doi: 10.1073/pnas.82.9.2627.

Primary structure and gene organization of human hepatitis A virus

R Najarian, D Caput, W Gee, S J Potter, A Renard, J Merryweather, G Van Nest, D Dina
Comparative Study

Primary structure and gene organization of human hepatitis A virus

R Najarian et al. Proc Natl Acad Sci U S A. 1985 May.

Abstract

The RNA genome of human hepatitis A virus (HAV) was molecularly cloned. Recombinant DNA clones representing the entire HAV RNA were used to determine the primary structure of the viral genome. The length of the viral genome is 7478 nucleotides. An open reading frame starting at nucleotide 734 and terminating at nucleotide 7415 encodes a polyprotein of Mr 251,940. Comparison of the HAV nucleotide sequence with that of other picornaviruses has failed to reveal detectable areas of homology. However, a computer analysis of the putative amino acid sequence of HAV and poliovirus demonstrated the existence of short areas of homology in virion protein 3 (VP3) and throughout the carboxyl-terminal portion of the polyproteins. In addition, extensive protein structural homologies with poliovirus were detected.

PubMed Disclaimer

References

    1. Biochemistry. 1974 Jan 15;13(2):211-22 - PubMed
    1. Biochemistry. 1974 Jan 15;13(2):222-45 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jan;74(1):59-63 - PubMed
    1. Nature. 1977 Jul 21;268(5617):208-13 - PubMed
    1. Intervirology. 1978;10(1):24-31 - PubMed

Publication types

Associated data

LinkOut - more resources