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. 1985 May;82(9):2910-4.
doi: 10.1073/pnas.82.9.2910.

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones

L Mengle-Gaw, H O McDevitt

Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones

L Mengle-Gaw et al. Proc Natl Acad Sci U S A. 1985 May.

Abstract

Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. We have isolated and determined the nucleotide sequences of cDNA and genomic clones for the I-E beta s gene and we present the predicted protein sequence for most of the E beta s polypeptide chain. The E beta s polypeptide shows 95% protein homology to the other cloned E beta alleles. Comparison of the protein sequences of five E beta alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E beta hypervariable regions may determine responsiveness to this antigen.

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References

    1. Eur J Biochem. 1973 Jul 2;36(1):32-8 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Mol Gen Genet. 1977 Jan 7;150(1):53-61 - PubMed
    1. Science. 1977 Apr 8;196(4286):180-2 - PubMed
    1. J Exp Med. 1977 Nov 1;146(5):1261-79 - PubMed

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