Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 May;82(9):3055-7.
doi: 10.1073/pnas.82.9.3055.

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase

J E Lisman

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase

J E Lisman. Proc Natl Acad Sci U S A. 1985 May.

Abstract

A mechanism is proposed for a molecular switch that can store information indefinitely, despite the complete turnover of the molecules that make up the switch. The design of the switch is based on known types of biochemical reactions. Central to the mechanism is a kinase that is activated by phosphorylation and capable of intermolecular autophosphorylation. It is shown that such a kinase and an associated phosphatase form a bistable chemical switch that can be turned on by an external stimulus and that is not reset by protein turnover.

PubMed Disclaimer

References

    1. J Biol Chem. 1968 May 10;243(9):2200-8 - PubMed
    1. Annu Rev Biochem. 1979;48:923-59 - PubMed
    1. Science. 1983 Nov 18;222(4625):771-8 - PubMed
    1. Methods Enzymol. 1983;99:176-86 - PubMed
    1. J Biol Chem. 1981 May 25;256(10):5029-36 - PubMed

Publication types

MeSH terms

Substances