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Case Reports
. 2018 Mar-Apr;28(2):153-156.
doi: 10.4103/ijn.IJN_54_17.

Renal Vein Thrombosis as Presentation of Non-M3 Acute Myeloid Leukemia in an Adult Patient

S K Sureka  1 , P Yadav  1 , P Kumar  2 , A Srivastava  1
Affiliations
Case Reports

Renal Vein Thrombosis as Presentation of Non-M3 Acute Myeloid Leukemia in an Adult Patient

S K Sureka et al. Indian J Nephrol. 2018 Mar-Apr.

Abstract

A 46-year-old male presented with left flank pain and was found to have left nephromegaly with renal vein and inferior vena cava (IVC) thrombus. On hematological evaluation, he had leukocytosis and thrombocytopenia. Further evaluation revealed acute myeloid leukemia (AML). Following initial cytoreductive therapy and supportive care for hyperleukocytosis, he underwent left simple nephrectomy with IVC thrombectomy. Postoperatively, he developed massive thrombosis of infrahepatic IVC with renal failure. Renal venous thrombosis as a rare presentation of AML in adults with leukemic hyperleukocytosis has not been reported. In the absence of clear guidelines, early diagnosis and management are desirable.

Keywords: Acute myeloid leukemia; renal vein thrombus; thrombectomy.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Contrast-enhanced computed tomographic scan showing thrombus in left renal vein (*) with enlarged nonenhanced left kidney
Figure 2
Figure 2
Leishman-stained bone marrow aspiration smears showing proliferation of large blasts with opened up chromatin and one to two prominent nucleoli and scanty cytoplasm. Inset showing granular positivity for myeloperoxidase stain in all the cells
Figure 3
Figure 3
(a) Left nephrectomy specimen showing thrombus in renal vein (black arrow and forceps) and normal renal artery (white arrow). (b) Coronal section of the resected specimen showing thrombus in intrarenal veins (small white arrows)
Figure 4
Figure 4
Postoperative contrast magnetic resonance imaging showed thrombus in infrahepatic inferior vena cava
See this image and copyright information in PMC

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