Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May 10:2018:3252765.
doi: 10.1155/2018/3252765. eCollection 2018.

Severity of Oral Mucositis in Children following Chemotherapy and Radiotherapy and Its Implications at a Single Oncology Centre in Durango State, Mexico

Ramón G Carreón-Burciaga  1 , Enrique Castañeda-Castaneira  2 , Rogelio González-González  1 , Nelly Molina-Frechero  2 , Enrique Gaona  2 , Ronell Bologna-Molina  3
Affiliations

Severity of Oral Mucositis in Children following Chemotherapy and Radiotherapy and Its Implications at a Single Oncology Centre in Durango State, Mexico

Ramón G Carreón-Burciaga et al. Int J Pediatr. .

Abstract

Background: Mucositis is an adverse effect of chemotherapy (QT) and/or radiotherapy (RT). The purpose of this study was to investigate the occurrence of oral mucositis in children undergoing cancer treatment.

Methods: Fifty-one children with cancer who had received QT, RT, or both (QT-RT) underwent clinical evaluations; World Health Organization criteria were used to establish the degree and severity of mucositis. The correlations between the clinical data, type of cancer, and therapy were statistically analysed.

Results: Mucositis was present in 88.23% of the patients; 57.78%, 7.78%, and 24.44% received QT, RT, and QT-RT, respectively. Severity scores of 1 and 2 were the most common; scores of 3-4 were observed in patients who received QT-RT or more than 7 treatment cycles. There was a significant association between mucositis, the type of treatment, and the number of cycles received (p < 0.05).

Conclusion: It is important to implement therapeutic protocols that help maintain excellent oral health and reduce the risk of oral mucositis. Stomatologists should be consulted to assess patients' oral cavities and provide preventive treatment prior to QT and/or RT administration. It is important to integrate a stomatologist into the oncological working group to focus on preventing and managing oral mucositis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of patients with and without mucositis according to gender, expressed as percentage of patients.
See this image and copyright information in PMC

References

    1. Zandieh S. O., Gershel J. C., Briggs W. M., Mancuso C. A., Kuder J. M. Revisiting predictors of parental health care-seeking behaviors for nonurgent conditions at one inner-city hospital. 2009;25(4):238–243. doi: 10.1097/pec.0b013e31819e350e. - DOI - PubMed
    1. Castellanos-Toledo A., Gutierrez-Vargas R. I., Portilla-Robertson J., López- Carrera Y. I., Asencio-Montiel I. J., Martínez-Avalos A. Factores de riesgo para lesiones orales en niños con leucemia aguda linfoblástica en quimioterapia. 2014;13(2):97–105.
    1. Ferreiro J. Adverse effects of treatment chemotherapy. 2003;100:69–74. doi: 10.1016/S0304-4858(03)74432-1. - DOI
    1. Sonis S. T., Elting L. S., Keefe D., et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. 2004;100(9):1995–2025. doi: 10.1002/cncr.20162. - DOI - PubMed
    1. Chen Y.-K., Hou H.-A., Chow J.-M., Chen Y.-C., Hsueh P.-R., Tien H.-F. The impact of oral herpes simplex virus infection and candidiasis on chemotherapy-induced oral mucositis among patients with hematological malignancies. 2011;30(6):753–759. doi: 10.1007/s10096-010-1148-z. - DOI - PubMed

LinkOut - more resources