An analysis of whether sleep disorder will result in postpartum depression

Abstract

Postpartum depression has become an important topic of concern in recent years. However, very few studies on the causes of postpartum depression exist, and the effects of prenatal sleep disorders on the development of postpartum depression among pregnant women have not been elucidated. This study aimed to understand the association between prenatal sleep disorders and postpartum depression. The National Health Insurance Research Database of Taiwan (between 2000 and 2010) was used to assess the effects of prenatal sleep disorder on the risk of postpartum depression using Cox regression analyses. Prenatal sleep disorder in pregnant women increased the risk of developing postpartum depression (the risk in the sleep disorder cases was 5.359-fold increased compared with control cases). In addition, regardless of postpartum week (≤ 6 weeks, 6-12 weeks, or > 12weeks), the risk of developing postpartum depression in pregnant women with prenatal sleep disorders were increased, by 5.461-fold (P < 0.001), 3.490-fold (P = 0.010), and 3.416-fold (P = 0.015), respectively, compared with pregnant women without sleep disorders. Pregnant women with prenatal sleep disorders exhibited increased risks of developing postpartum depression. For pregnant women with prenatal sleep disorder, postpartum intervention measures should be provided as early as possible to reduce the risk of developing postpartum depression.

Keywords: national health insurance research database (NHIRD); postpartum depression; sleep disorder.

Figure 1. The flowchart of study sample selection from National Health Insurance Research Database in Taiwan

Figure 2. Kaplan–Meier for cumulative risk of postpartum depression among pregnancy woman aged 18–50 after deliver in 1-year tracking stratified by sleep disorder with log-rank test

Figure 3. Association between sleep disorder and postpartum depression stratified by times of postpartum and number of births by using Cox regression

wks = weeks, Adjusted HR = Adjusted Hazard ration: Adjusted for the variables listed in Table 3 Interaction (Times of postpartum × Number of births) P < 0.001.