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Review
. 2018 May 16:2018:9285854.
doi: 10.1155/2018/9285854. eCollection 2018.

Protein Based Nanostructures for Drug Delivery

Deepali Verma  1 , Neha Gulati  1 , Shreya Kaul  1 , Siddhartha Mukherjee  1 , Upendra Nagaich  1
Affiliations
Review

Protein Based Nanostructures for Drug Delivery

Deepali Verma et al. J Pharm (Cairo). .

Abstract

The key role of protein based nanostructures has recently revolutionized the nanomedicine era. Protein nanoparticles have turned out to be the major grounds for the transformation of different properties of many conventional materials by virtue of their size and greater surface area which instigates them to be more reactive to some other molecules. Protein nanoparticles have better biocompatibilities and biodegradability and also have the possibilities for surface modifications. These nanostructures can be synthesized by using protein like albumin, gelatin, whey protein, gliadin, legumin, elastin, zein, soy protein, and milk protein. The techniques for their fabrication include emulsification, desolvation, complex coacervation, and electrospray. The characterization parameters of protein nanoparticles comprise particle size, particle morphology, surface charge, drug loading, determination of drug entrapment, and particle structure and in vitro drug release. A plethora of protein nanoparticles applications via different routes of administration are explored and reported by eminent researchers which are highlighted in the present review along with the patents granted for protein nanoparticles as drug delivery carriers.

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Figures

Figure 1
Figure 1
Pictorial presentation of positive aspects and negative aspects of protein nanoparticles.
Figure 2
Figure 2
Chemical structure of (a) gliadin, (b) legumin, (c) elastin, and (d) zein.
Figure 3
Figure 3
Diagrammatic representation of emulsification technique for protein nanoparticles formulation.
Figure 4
Figure 4
Flowchart presentation of desolvating/coacervation technique.
Figure 5
Figure 5
Pictorial presentation of complex coacervation technique for protein nanoparticles preparation.
Figure 6
Figure 6
Preparation of protein nanoparticles by electrospray technique.
Figure 7
Figure 7
Pictorial presentation for characterization of protein nanoparticles.
Figure 8
Figure 8
Application of protein nanoparticles.
Figure 9
Figure 9
Schematic illustration of pulmonary route of nanoparticles.
Figure 10
Figure 10
Various transport pathway through blood brain barrier.
See this image and copyright information in PMC

References

    1. Coester C., Nayyar P., Samuel J. In vitro uptake of gelatin nanoparticles by murine dendritic cells and their intracellular localisation. 2006;62(3):306–314. doi: 10.1016/j.ejpb.2005.09.009. - DOI - PubMed
    1. Verma R. K., Garg S. Current status of drug delivery technologies and future directions. 2001;25:1–14.
    1. Lohcharoenkal W., Wang L., Chen Y. C., Rojanasakul Y. Protein nanoparticles as drug delivery carriers for cancer therapy. 2014;2014:12. doi: 10.1155/2014/180549.180549 - DOI - PMC - PubMed
    1. Pathak Y., Thassu D. Vol. 191. New York, NY, USA: Informa Healthcare; 2009. (Desgin nad formulation of protein based NPDDS).
    1. Jahanshahi M., Zhang Z., Lyddiatt A. Subtractive chromatography for purification and recovery of nano-bioproducts. 2005;152(3):121–126. doi: 10.1049/ip-nbt:20045004. - DOI - PubMed