Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May;13(5):809-810.
doi: 10.4103/1673-5374.232471.

Silkworm silk biomaterials for spinal cord repair: promise for combinatorial therapies

Anna Varone  1 , Ann Marie Rajnicek  1 , Wenlong Huang  1
Affiliations

Silkworm silk biomaterials for spinal cord repair: promise for combinatorial therapies

Anna Varone et al. Neural Regen Res. 2018 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared

Figures

Figure 1
Figure 1
Degummed Antheraea pernyi filaments (DAPF) and neuronal growth alignment. (A) Scanning electron microscopy (SEM) image of a longitudinal view of a bundle of DAPF. (B) SEM image of a postnatal rat cortical neuron extending its longest neurite along DAPF after two days in culture. (C) Fluorescence image of an embryonic Xenopus laevis spinal cord neurons extending neurites along a DAPF after 5 hours in culture. Scale bars: 100 µm in A, 10 µm in B, C.
Figure 2
Figure 2
Development of degummed Antheraea pernyi filaments (DAPF) for in vivo spinal cord injury (SCI) models. (A) DAPF can be dissolved and made into a hydrogel form which can be injected directly in a large and undefined cavity typical of contusive SCI. (B) DAPF can also be embedded in a silk hydrogel and implanted in a transection SCI in which the lesion gap is small and with a defined geometry.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ahuja CS, Nori S, Tetreault L, Wilson J, Kwon B, Harrop J, Choi D, Fehlings MG. Traumatic spinal cord injury-repair and regeneration. Neurosurgery. 2017;80:S9–S22. - PubMed
    1. Floren M, Bonani W, Dharmarajan A, Motta A, Migliaresi C, Tan W. Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype. Acta Biomater. 2016;31:156–166. - PMC - PubMed
    1. Hersel U, Dahmen C, Kessler H. RGD modified polymers: Biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003;24:4385–4415. - PubMed
    1. Hopkins AM, De Laporte L, Tortelli F, Spedden E, Staii C, Atherton TJ, Hubbell JA, Kaplan DL. Silk hydrogels as soft substrates for neural tissue engineering. Adv Funct Mater. 2013;23:5140–5149.
    1. Huang W, Begum R, Barber T, Ibba V, Tee NCH, Hussain M, Arastoo M, Yang Q, Robson LG, Lesage S, Gheysens T, Skaer NJV, Knight DP, Priestley JV. Regenerative potential of silk conduits in repair of peripheral nerve injury in adult rats. Biomaterials. 2012;33:59–71. - PubMed