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Editorial
. 2018 Jun;38(6):988-990.
doi: 10.1111/liv.13726.

Detecting liver injury non-invasively using hyperpolarized 13 C MRI

Affiliations
Editorial

Detecting liver injury non-invasively using hyperpolarized 13 C MRI

Cornelius von Morze. Liver Int. 2018 Jun.
No abstract available

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Conflict of interest statement

Conflict of interest: None

Figures

Figure
Figure
Illustration of the process of hyperpolarized (HP) 13C magnetic resonance imaging (MRI) via the method of dissolution dynamic nuclear polarization (DNP). After pre-polarization and rapid dissolution (left), the HP [1-13C]pyruvate solution is rapidly transported to the MRI scanner and injected into the subject. 13C MRI data is collected (right) showing not only the distribution of the substrate (pyr) but also its local conversion to [1-13C]lactate (lac) and [1-13C]alanine (ala) via key biochemical reactions.

Comment on

References

    1. Moon C-M, Shin S-S, Lim N-Y, et al. Metabolic alterations in a rat model of hepatic ischemia reperfusion injury: in vivo hyperpolarized 13C MRS and metabolic imaging. Liver Int. 2018 doi: 10.1111/liv.13695. - DOI - PubMed
    1. Yoshihara HAI, Bastiaansen JAM, Berthonneche C, Comment A, Schwitter J. An intact small animal model of myocardial ischemia-reperfusion: Characterization of metabolic changes by hyperpolarized 13C MR spectroscopy. Am J Physiol Heart Circ Physiol. 2015;309:H2058–66. - PubMed
    1. Baligand C, Qin H, True-Yasaki A, et al. Hyperpolarized C-13 magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR in Biomedicine. 2017;30 - PMC - PubMed
    1. Ardenkjaer-Larsen JH, Fridlund B, Gram A, et al. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci USA. 2003;100:10158–10163. - PMC - PubMed
    1. Golman K, in’t Zandt R, Thaning M. Real-time metabolic imaging. Proc Natl Acad Sci USA. 2006;103:11270–11275. - PMC - PubMed

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