Emerging role of sperm-associated antigen 9 in tumorigenesis
- PMID: 29864900
- DOI: 10.1016/j.biopha.2018.04.168
Emerging role of sperm-associated antigen 9 in tumorigenesis
Abstract
Sperm-associated antigen 9 (SPAG9) is a new member of cancer testis antigen and belongs to c-Jun NH2-terminal kinase (JNK) interacting protein (JIP) family. SPAG9 is highly expressed in a variety of tumors patients, and induces immune response in the host. SPAG9 regulates JNK and mitogen-activated protein kinases (MAPKs) signaling pathways which promote the growth, metastasis and drug resistance of tumors. In addition, SPAG9 modulates cell cycle progression and upregulates matrix metalloproteinases during the progression of tumors. Silencing SPAG9 expression could suppress the development of tumors. This review summarizes recent progress in our understanding of the emerging role of SPAG9 in tumorigenesis and highlights the potential of SPAG9 as a novel target for cancer diagnosis and therapy.
Keywords: Cell cycle; Diagnosis; SPAG9; Therapy; Tumor.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.
Similar articles
-
Sperm-associated antigen 9, a novel cancer testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer.Clin Cancer Res. 2007 Mar 1;13(5):1421-8. doi: 10.1158/1078-0432.CCR-06-2340. Clin Cancer Res. 2007. PMID: 17332284
-
Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH2 -terminal kinase (JNK) interacting protein exclusively expressed in testis.Keio J Med. 2005 Jun;54(2):66-71. doi: 10.2302/kjm.54.66. Keio J Med. 2005. PMID: 16077255
-
Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.Biochem J. 2005 Jul 1;389(Pt 1):73-82. doi: 10.1042/BJ20041577. Biochem J. 2005. PMID: 15693750 Free PMC article.
-
Immunogenicity and contraceptive potential of recombinant human sperm associated antigen (SPAG9).J Reprod Immunol. 2005 Oct;67(1-2):69-76. doi: 10.1016/j.jri.2005.06.004. Epub 2005 Sep 6. J Reprod Immunol. 2005. PMID: 16143403 Review.
-
The Emerging Role of CSN6 in Biological Behavior and Cancer Progress.Anticancer Agents Med Chem. 2019;19(10):1198-1204. doi: 10.2174/1871520619666190408142131. Anticancer Agents Med Chem. 2019. PMID: 30961513 Review.
Cited by
-
The Contributions of Cancer-Testis and Developmental Genes to the Pathogenesis of Keratinocyte Carcinomas.Cancers (Basel). 2022 Jul 26;14(15):3630. doi: 10.3390/cancers14153630. Cancers (Basel). 2022. PMID: 35892887 Free PMC article. Review.
-
Identification and Validation of a Cancer-Testis Antigen-Related Signature to Predict the Prognosis in Stomach Adenocarcinoma.J Cancer. 2024 May 11;15(11):3596-3611. doi: 10.7150/jca.91842. eCollection 2024. J Cancer. 2024. PMID: 38817874 Free PMC article.
-
Sperm Associated Antigens: Vigorous Influencers in Life.Cell J. 2021 Oct;23(5):495-502. doi: 10.22074/cellj.2021.7377. Epub 2021 Oct 30. Cell J. 2021. PMID: 34837675 Free PMC article. Review.
-
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19.Front Cardiovasc Med. 2020 Nov 3;7:582399. doi: 10.3389/fcvm.2020.582399. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 33240937 Free PMC article.
-
Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome).Genet Mol Biol. 2025 Jan 20;48(1):e20240094. doi: 10.1590/1678-4685-GMB-2024-0094. eCollection 2025. Genet Mol Biol. 2025. PMID: 39846792 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
