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Review
. 2018 Jul;46(7):2549-2557.
doi: 10.1177/0300060518774127. Epub 2018 Jun 4.

Tuberculosis-associated IgA nephropathy

Yamei Wang  1   2 , Yuhong Tao  1
Affiliations
Review

Tuberculosis-associated IgA nephropathy

Yamei Wang et al. J Int Med Res. 2018 Jul.

Abstract

Immunoglobulin A nephropathy (IgAN) is the most frequent pathological diagnosis of tuberculosis (TB)-associated glomerulonephritis. Diagnosing TB-associated IgAN (TB-IgAN) is difficult because of its non-specific and insidious symptoms. An inaccurate diagnosis of TB-IgAN could result in the spread of TB and reduced renal function. Haematuria and proteinuria in conjunction with TB should be assessed because of the potential for diagnosis of IgAN. Renal biopsy is important in securing an accurate diagnosis prior to initiating treatment. Detection of Mycobacterium tuberculosis DNA and assessment of early secreted antigenic target of 6 kDa in renal biopsy tissues may have great potential diagnostic value in patients with TB-IgAN. Anti-TB therapy can effectively alleviate TB and TB-IgAN.

Keywords: Immunoglobulin A nephropathy; Mycobacterium tuberculosis; T cell-secreted transforming growth factor β1; glomerulonephritis; haematuria; renal function; tuberculosis; γδT cells.

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Figures

Figure 1.
Figure 1.
Preliminary pathogenesis of tuberculosis-associated immunoglobulin A nephropathy.
See this image and copyright information in PMC

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