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. 2018 Sep;92(1):34-36.
doi: 10.1016/j.diagmicrobio.2018.04.004. Epub 2018 Apr 14.

Impact of IFNL4-∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals

Lisa I Backus  1 , Troy A Shahoumian  2 , Pamela S Belperio  2 , Mark Winters  3 , Ludmila Prokunina-Olsson  4 , Thomas R O'Brien  4 , Mark Holodniy  5
Affiliations

Impact of IFNL4-∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals

Lisa I Backus et al. Diagn Microbiol Infect Dis. 2018 Sep.

Abstract

In direct acting antiviral (DAA)-treated HCV genotype 1, the sustained virologic response rate with the ∆G/∆G genotype of IFNL4 rs368234815 (86.8%) was significantly lower than with ∆G/TT (95.9%, P = 0.03) or TT/TT (98.6%, P = 0.01). The SVR odds ratio for ∆G/∆G compared to TT/TT was 0.10 (P = 0.03). IFNL4 genotype might predict DAA-response.

Keywords: IFNL4; SVR; hepatitis C virus, DAA therapy, Veterans.

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