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Review
. 2018 Jun 4;10(6):178.
doi: 10.3390/cancers10060178.

p53 and the Viral Connection: Back into the Future ‡

Ronit Aloni-Grinstein  1   2 , Meital Charni-Natan  3 , Hilla Solomon  4 , Varda Rotter  5
Affiliations
Review

p53 and the Viral Connection: Back into the Future ‡

Ronit Aloni-Grinstein et al. Cancers (Basel). .

Abstract

The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections.

Keywords: HIV-1; HSV-1; SV40; cancer; influenza; p53; papilloma; vaccinia; virus; zika.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Various viral strategies to manipulate p53-depndent host defense.
See this image and copyright information in PMC

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