Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 14:10:134.
doi: 10.3389/fnagi.2018.00134. eCollection 2018.

Role of Ionizing Radiation in Neurodegenerative Diseases

Neel K Sharma  1 , Rupali Sharma  2 , Deepali Mathur  3 , Shashwat Sharad  4 , Gillipsie Minhas  5 , Kulsajan Bhatia  6 , Akshay Anand  5 , Sanchita P Ghosh  1
Affiliations
Review

Role of Ionizing Radiation in Neurodegenerative Diseases

Neel K Sharma et al. Front Aging Neurosci. .

Abstract

Ionizing radiation (IR) from terrestrial sources is continually an unprotected peril to human beings. However, the medical radiation and global radiation background are main contributors to human exposure and causes of radiation sickness. At high-dose exposures acute radiation sickness occurs, whereas chronic effects may persist for a number of years. Radiation can increase many circulatory, age related and neurodegenerative diseases. Neurodegenerative diseases occur a long time after exposure to radiation, as demonstrated in atomic bomb survivors, and are still controversial. This review discuss the role of IR in neurodegenerative diseases and proposes an association between neurodegenerative diseases and exposure to IR.

Keywords: CNS; aging; hypoxia; ionizing radiation; neurodegenerative diseases.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Ionizing radiation cause neural injury leads to neurodegenerative diseases.
FIGURE 2
FIGURE 2
Inflammation-mediated mechanisms in radiation induced brain injury. (Left) Healthy brain secretes CD55, CD47, CX3CL1, CD20 and have intact neurons. (Right) Radiations affect the neurons and microglia in brain. Reproduced with permission (Lumniczky et al., 2017).
FIGURE 3
FIGURE 3
Low dose Ionizing radiation confer not only the neuroprotection but also activate reparative mechanisms. (A) Neuroinflammation may decrease by low dose ionizing radiation and can lead in increased antioxidants and reduced oxidative stress. (B) Neuroinflammation can be provoked by high dose ionizing radiation lead to microglia activation and ROS which can affect the cell functioning. Reproduced with permission (Betlazar et al., 2016).
See this image and copyright information in PMC

References

    1. Abayomi O. K. (1996). Pathogenesis of irradiation-induced cognitive dysfunction. 35 659–663. 10.3109/02841869609083995 - DOI - PubMed
    1. Acharya M. M., Patel N. H., Craver B. M., Tran K. K., Giedzinski E., Tseng B. P., et al. (2015). Consequences of low dose ionizing radiation exposure on the hippocampal microenvironment. 10:e0128316. 10.1371/journal.pone.0128316 - DOI - PMC - PubMed
    1. Amoaku W. M., Frew L., Mahon G. J., Gardiner T. A., Archer D. B. (1989). Early ultrastructural changes after low-dose X-irradiation in the retina of the rat. 3(Pt 5) 638–646. 10.1038/eye.1989.98 - DOI - PubMed
    1. Amundson S. A. (2008). Functional genomics and a new era in radiation biology and oncology. 58 491–500. 10.1641/B580606 - DOI - PMC - PubMed
    1. Andreassi M. G., Piccaluga E., Gargani L., Sabatino L., Borghini A., Faita F., et al. (2015). Subclinical carotid atherosclerosis and early vascular aging from long-term low-dose ionizing radiation exposure: a genetic, telomere, and vascular ultrasound study in cardiac catheterization laboratory staff. 8 616–627. 10.1016/j.jcin.2014.12.233 - DOI - PubMed

LinkOut - more resources