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. 2018 May 28:6:e4917.
doi: 10.7717/peerj.4917. eCollection 2018.

The relationship between body mass index and pain, disease activity, depression and anxiety in women with fibromyalgia

Burhan Fatih Koçyiğit  1 , Ramazan Azim Okyay  2
Affiliations

The relationship between body mass index and pain, disease activity, depression and anxiety in women with fibromyalgia

Burhan Fatih Koçyiğit et al. PeerJ. .

Abstract

Background: Obesity is a possible factor which affects severity of symptoms and disease activity in fibromyalgia syndrome (FMS). The aim of our study was to determine the association between body mass index (BMI) and pain, tender point count (TPC), disease activity, anxiety and depression in patients with FMS.

Methods: This was a descriptive study. A total of 124 female FMS patients between 18 and 55 years of age were enrolled. FMS patients were evaluated with visual analog scale (VAS), fibromyalgia impact questionnaire (FIQ), Hamilton anxiety scale (HAM-A) and Hamilton depression scale (HAM-D). Patients were divided into three groups according to BMI levels: normal weight, overweight and obese. Normal weight was defined as BMI 18.5-24.9, overweight as BMI 25.0-29.9 and obesity as BMI ≥ 30. We assessed the BMI status and its association with symptom severity in patients with FMS.

Results: Significant differences were detected in VAS, TPC, FIQ and HAM-D among the groups (p < 0.05). There were no significant differences between the groups in HAM-A (p = 0.328). The highest scores were found in the obese group. Significant positive correlations were determined between BMI levels and VAS, TPC, FIQ and HAM-D (r = 0.277, p = 0.002; r = 0.384, p < 0.001; r = 0.292, p = 0.001; r = 0.357, p < 0.001).

Discussion: Obese female FMS patients had higher levels of pain, TPC, disease activity and depression. BMI was significantly and positively correlated with clinical manifestations of FMS. Therefore, FMS treatment programs should include weight loss strategies.

Keywords: Anxiety; Body mass index; Depression; Disease activity; Fibromyalgia; Obesity.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

    1. Alciati A, Atzeni F, Grassi M, Caldirola D, Sarzi-Puttini P, Angst J, Perna G. Features of mood associated with high body weight in females with fibromyalgia. Comprehensive Psychiatry. 2018;80:57–64. doi: 10.1016/j.comppsych.2017.08.006. - DOI - PubMed
    1. Aparicio VA, Ortega FB, Carbonell-Baeza A, Gatto-Cardia C, Sjöström M, Ruiz JR, Delgado-Fernández M. Fibromyalgia’s key symptoms in normal-weight, overweight, and obese female patients. Pain Management Nursing. 2013;14(4):268–276. doi: 10.1016/j.pmn.2011.06.002. - DOI - PubMed
    1. Bartley EJ, Robinson ME, Staud R. Pain and fatigue variability patterns distinguish subgroups of fibromyalgia patients. Journal of Pain. 2018;19(4):372–381. doi: 10.1016/j.jpain.2017.11.014. - DOI - PMC - PubMed
    1. Benazzi F, Akiskal HS. Refining the evaluation of bipolar II: beyond the strict SCID-CV guidelines for hypomania. Journal of Affective Disorders. 2003;73(1–2):33–38. doi: 10.1016/S0165-0327(02)00327-0. - DOI - PubMed
    1. Bond DS, Roth J, Nash JM, Wing RR. Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment. Obesity Reviews. 2011;12(5):e362–e371. doi: 10.1111/j.1467-789X.2010.00791.x. - DOI - PMC - PubMed