Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jul 5;20(8):1142-1143.
doi: 10.1093/neuonc/noy080.

Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma

Giuseppe Lombardi  1 , Alessandro Della Puppa  2 , Marina Paola Gardiman  3 , Sabrina Rossi  4 , Cinzia Candiotto  5 , Lucia Zanatta  4 , Roberta Bertorelle  5 , Anita De Rossi  6   7 , Matteo Fassan  3 , Vittorina Zagonel  1
Affiliations
Comment

Discordance of IDH mutational status between lesions in an adult patient with multifocal glioma

Giuseppe Lombardi et al. Neuro Oncol. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
(A, C) Radiological and pathological characteristics of the IDH wild-type GBM and (B, D) IDH-mutant diffuse astrocytoma. Scale bars (C, D) = 100 μm. (E) FISH analyses showing monosomy of chromosome 10 (Vysis LSI phosphatase and tensin homolog in orange and chromosome 10 enumeration probe [CEP10] in green) and (F) homozygous deletion of 9p21 (CDKN2A) (Vysis CDKN2A in orange and CEP9 in green) in the IDH wild-type GBM. (G) Sanger sequencing of IDH-mutant diffuse astrocytoma and (H) IDH wild-type GBM sample.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abou-El-Ardat K, Seifert M, Becker K et al. . Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. Neuro Oncol. 2017;19(4):546–557. - PMC - PubMed
    1. Ozawa T, Riester M, Cheng YK. et al. Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma. Cancer Cell. 2014;26(2):288–300. - PMC - PubMed
    1. Barthel FP, Wesseling P, Verhaak RGW. Reconstructing the molecular life history of gliomas. Acta Neuropathol. 2018;135(5):649–670. - PMC - PubMed
    1. Eckel-Passow JE, Lachance DH, Molinaro AM et al. . Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med. 2015;372(26):2499–2508. - PMC - PubMed
    1. Galuppini F, Opocher E, Tabori U et al. . Concomitant IDH wild-type glioblastoma and IDH1-mutant anaplastic astrocytoma in a patient with constitutional mismatch repair deficiency syndrome. Neuropathol Appl Neurobiol. 2018;44(2):233–239. - PubMed

Substances