Considering the Genetic and Epigenetic Signature of Early Adversity Within a Biopsychosocial Framework

Affiliations

¹ From the Department of Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, N.Y.; and the Department of Psychiatry, Mount Sinai School of Medicine, New York.

Editorial

Rachel Yehuda et al. Am J Psychiatry. 2018.

. 2018 Jun 1;175(6):491-492.

doi: 10.1176/appi.ajp.2018.18020156.

¹ From the Department of Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, N.Y.; and the Department of Psychiatry, Mount Sinai School of Medicine, New York.

No abstract available

Keywords: DNA Methylation; Diagnosis and Classification; Epigenetics; Maltreatment; Stress.

Comment on

Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood.
Marzi SJ, Sugden K, Arseneault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon E, Moffitt TE, Odgers CL, Pariante C, Poulton R, Williams BS, Wong CCY, Mill J, Caspi A. Marzi SJ, et al. Am J Psychiatry. 2018 Jun 1;175(6):517-529. doi: 10.1176/appi.ajp.2017.17060693. Epub 2018 Jan 12. Am J Psychiatry. 2018. PMID: 29325449 Free PMC article.
Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.
Peterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS. Peterson RE, et al. Am J Psychiatry. 2018 Jun 1;175(6):545-554. doi: 10.1176/appi.ajp.2017.17060621. Epub 2018 Mar 2. Am J Psychiatry. 2018. PMID: 29495898 Free PMC article.