Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Jun 5;13(6):e0198602.
doi: 10.1371/journal.pone.0198602. eCollection 2018.

The prognostic significance of long noncoding RNAs in bladder cancer: A meta-analysis

Yuexin Xia  1 , Zhiyuan Liu  2 , Weijian Yu  1 , Shihang Zhou  1 , Linnan Shao  1 , Wenqian Song  1 , Ming Liu  3
Affiliations
Meta-Analysis

The prognostic significance of long noncoding RNAs in bladder cancer: A meta-analysis

Yuexin Xia et al. PLoS One. .

Expression of concern in

Abstract

Introduction: Bladder cancer (BC) is one of the most common urologic malignancies and it is urgently needed to identify novel potential prognostic biomarkers for predicting prognosis and progression of patients with BC in clinical practice. Previous research has revealed that long noncoding RNAs (lncRNAs) played critical roles in BC, and may serve as novel potential prognostic biomarkers in patients with BC. Therefore, we conducted this meta-analysis to clarify the prognostic potential of lncRNAs in BC patients.

Methods: A comprehensive search was performed in PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). According to the predefined exclusion and inclusion criteria, a total of 9 recently published articles comprising 13 lncRNAs and 666 BC patients were included into this meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between lncRNAs expression and survival outcomes. We also analyzed the odds ratio (ORs) and 95% confidence intervals (CIs) to assess the association between lncRNAs expression and clinicopathological characteristics, including histological grade, gender, multifocality, tumor size, and tumor stage.

Results: Our results revealed that high lncRNAs expression was associated with shorter overall survival in Asian BC patients (pooled HR = 2.32, 95% CI: 1.35-4.00, P = 0.002, random-effect). High lncRNAs expression levels were significantly associated with histological grade (G2-G3 vs. G1: OR = 3.857, 95%CI: 1.293-11.502, P = 0.015, random-effect).

Conclusions: In summary, this meta-analysis has demonstrated that lncRNAs could be used as potential prognostic markers for BC and high lncRNAs expression could predict poor prognosis among Asian BC patients.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart of literature selection process in the meta-analysis.
Fig 2
Fig 2. Forest plots for the association between lncRNAs expression and OS of BC patients.
Fig 3
Fig 3. Forest plots for the association between lncRNAs expression and RFS of BC patients.
Fig 4
Fig 4. Funnel plot of the publication bias.
(A) Funnel plot of the publication bias for overall survival. (B) Funnel plot of the publication bias for recurrence-free survival. (C) Funnel plot of the publication bias for gender. (D) Funnel plot of the publication bias for histological classifcation; (E) Funnel plot of the publication bias for multifocality.
Fig 5
Fig 5. Sensitivity analysis of the effect of individual studies on the pooled HRs for lncRNAs expression and OS of BC patients.
See this image and copyright information in PMC

References

    1. GLOBOCAN. Cancer incidence, mortality and prevalence worldwide in 2012 Lyon, France: International Agency Research on Cancer, 2012. Available from: http://globocan.iarc.fr
    1. Babjuk M, Burger M, Zigeuner R, Kaasinen E, Böhle A, Palou-Redorta J, et al. EAU guidelines on non-muscle invasive urothelial carcinoma of the 2011 update. Eur Urol 2013;64:639–653. doi: 10.1016/j.eururo.2013.06.003 - DOI - PubMed
    1. Van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, et al. Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy. Eur Urol. 2009;56:430–442. doi: 10.1016/j.eururo.2009.06.028 - DOI - PubMed
    1. Kim WJ, Kim EJ, Kim SK, Kim YJ, Ha YS, Jeong P, et al. Predictivevalue of progression-related gene classifier in primary non-muscle invasive bladder cancer. Mol Cancer. 2010;9:3 doi: 10.1186/1476-4598-9-3 - DOI - PMC - PubMed
    1. Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, et al.Long non-coding RNA HOTAIR regulates Polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 2011;71:6320–6. doi: 10.1158/0008-5472.CAN-11-1021 - DOI - PubMed

Publication types