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Comment
. 2018 Jun 4;28(11):R674-R677.
doi: 10.1016/j.cub.2018.04.032.

Nuclear Pore Complexes: Global Conservation and Local Variation

Guillaume Holzer  1 , Wolfram Antonin  2
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Nuclear Pore Complexes: Global Conservation and Local Variation

Guillaume Holzer et al. Curr Biol. .
Free article

Abstract

Nuclear pore complexes are the transport gates to the nucleus. Most proteins forming these huge complexes are evolutionarily conserved, as is the eightfold symmetry of these complexes. A new study reporting the structure of the yeast nuclear pore complex now shows striking differences from its human counterpart.

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  • Integrative structure and functional anatomy of a nuclear pore complex.
    Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP. Kim SJ, et al. Nature. 2018 Mar 22;555(7697):475-482. doi: 10.1038/nature26003. Epub 2018 Mar 14. Nature. 2018. PMID: 29539637 Free PMC article.

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