Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985;21(5):479-89.
doi: 10.1007/BF00430931.

The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes

C N'Guyen, R Sodoyer, J Trucy, T Strachan, B R Jordan
Comparative Study

The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes

C N'Guyen et al. Immunogenetics. 1985.

Abstract

A cosmid clone containing two class I sequences was found to cause expression of the HLA-AW24 protein after transfection into mouse L cells. The restriction map of this cosmid shows extensive homology over 26 kb with the map of the HLA-A3 region obtained from cosmids of the same library, constructed with DNA from an HLA-A3/HLA-AW24 heterozygote, but diverges over the remaining 14 kb. The HLA-AW24 gene was subcloned from this cosmid and its nucleotide sequence was determined. Amino acid and, more strikingly, nucleotide sequence comparisons with other HLA alleles indicate that the A locus alleles are more closely related to each other than to alleles from other HLA loci. A very skewed distribution of silent substitutions is apparent, and the occurrence of clustered multiple substitutions hints at gene-conversion-like events.

PubMed Disclaimer

References

    1. Cell. 1983 Aug;34(1):169-77 - PubMed
    1. J Immunol. 1985 Apr;134(4):2727-33 - PubMed
    1. Cell. 1980 Mar;19(3):753-64 - PubMed
    1. EMBO J. 1984 Apr;3(4):887-94 - PubMed
    1. Hum Immunol. 1984 Sep;11(1):31-45 - PubMed

Publication types

Associated data

LinkOut - more resources