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. 2016 Oct 20;30(20):1597-1600.
doi: 10.13201/j.issn.1001-1781.2016.20.004.

[Association of CTLA-4 gene polymorphism in allergic rhinitis with asthma or not in children]

[Article in Chinese]
S H Song  1 , X Q Wang  2 , Y Shen  2 , P Wei  3 , S L Hong  2 , X Ke  2
Affiliations

[Association of CTLA-4 gene polymorphism in allergic rhinitis with asthma or not in children]

[Article in Chinese]
S H Song et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. .

Abstract

Objective:To evaluate the involvement of the cytotoxic T lymphocyte associated antigen (CTLA-4) gene polymorphisms in susceptibility of allergic rhinitis(AR) with/without asthma in children.Method:Three hundred and two AR children,288 AR with asthma children,and 327 healthy Chinese Han children were enrolled in the study.The SNPs of CTLA-4(rs3087243,rs11571302,rs11571315,rs231725,rs35219727,and rs4553808) were sequenced using a PCR restriction fragment length polymorphism assay.Result: An increased frequency of the AA genotype and A allele in rs3087243 of CTLA-4 was found in AR with asthma group.For rs231725,AA genotype and A allele were obviously increased in AR group, while they were significantly decreased in AR with asthma group(P<0.05).Conclusion:We found a significant association between CTLA-4 gene polymorphism and AR with asthma in Chinese Han children, which might be an autoimmunity risk factor for AR with asthma.

Keywords: asthma; child; polymorphism,single nucleotide; rhinitis,allergic; the cytotoxic T-lymphocyte associated antigen 4.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

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