[To study the effect of intratympanic injection with mouse nerve growth factor and methylprednisolone on sudden deafness]

Abstract

Objective:To observe the efficacy of intratympanic injection with mouse nerve growth factor and methylprednisolone on the treatment of sudden deafness.Method:One hundred and forty-nine patients diagnosed as sudden deafness were randomly divided into the control group and the observation group. The control group was treated with the conventional medication and methylprednisolone(0.5 ml)+0.9%NaCl(0.5 ml), once every three days for two weeks. The observation group was added with mouse nerve growth factor(0.5 ml) once every three days for two weeks.Result:The total effective rate in the observation group of hearing, tinnitus and vertigo were respective 93.4%, 77.8%,85.2%, which were higher than 80.8%, 63.0%, 67.2%.in the control group.And the differences between them had statistical significance(P< 0.05).Conclusion:Effect of the intratympanic injection with mouse nerve growth factor and methylprednisolone on the treatment of sudden deafness is obvious, which can effectively improve hearing level, and relieve tinnitus and vertigo.

Keywords: intratympanic injection; methylprednisolone; mouse nerve growth factor; sudden deafness.